HomeHealthRoyal Papworth Hospital ‘lungs in a box’ could boost transplants

Royal Papworth Hospital ‘lungs in a box’ could boost transplants


Royal Papworth Hospital Donated lungs inside a special dome shaped incubator. The dome is plastic and you can see the tubes carrying liquid oxygen and nitrates going into the trachea of the lungs. They are being inflated by a ventilator
Royal Papworth Hospital

The machine, nicknamed “lungs in a box”, is designed to mimic the human body

A new machine which keeps lungs alive outside of the body could “transform” the number of people receiving transplants, surgeons hope.

The breakthrough has come at Royal Papworth Hospital in Cambridgeshire after it became the first in the UK to pilot the use of the XPS system.

The machine, nicknamed “lungs in a box”, mimics the human body and surgeon Marius Berman said it could increase the number of transplants by 30%.

Daniel Evans-Smith, a 49-year-old event manager from Northampton, was the first to receive a double lung transplant using the system on the NHS and said he was “immensely grateful”.


Royal Papworth Hospital Daniel Evans-Smith looks at the camera from his hospital bed. He is dressed in a hospital gown with a blanket over his shoulders. He had a beard and greying hair. You can see oxygen pipes in the background which are not attached to Mr Evans-Smith
Royal Papworth Hospital

David Evans-Smith had the double lung transplant in the summer and is hoping to return to work in three to six months

Some 81% of lungs are rejected for transplantation because they are inflamed or in poor condition.

The machine improves the health of the organs, by using a ventilator to inflate and deflate the lungs. A liquid containing nutrients and oxygen is also pumped through them.

The technique is called ex vivo lung perfusion (EVLP). It means donated lungs which are considered “borderline” for use can be reconditioned and used, instead of being discarded.

The organs are kept at body temperature, for up to six hours.

The one-year pilot has been funded by NHS England and the Royal Papworth charity.

The machine was only previously used in UK research trials.


Royal Papworth Hospital Daniel Evans-Smith lying on a bed in the operating theatre at Royal Papworth hospital. He has his eyes open and a wristband on and is looking up at the ceiling. A surgeon stands behind him wearing a hair net and scrubs. Two nurses are checking equipment to his left and are wearing scrubs and aprons
Royal Papworth Hospital

Mr Evans-Smith waited eight weeks for a transplant using the machine. The average wait in the UK is 18 months

Some 81% of lungs are rejected for transplantation because they are inflamed or in poor condition.

The machine improves the health of the organs, by using a ventilator to inflate and deflate the lungs. A liquid containing nutrients and oxygen is also pumped through them.

The technique is called ex vivo lung perfusion (EVLP). It means donated lungs which are considered “borderline” for use can be reconditioned and used, instead of being discarded.

The organs are kept at body temperature, for up to six hours.

The one-year pilot has been funded by NHS England and the Royal Papworth charity.

The machine was only previously used in UK research trials.